Department of Dermatology

Adriana Larregina, MD, PhD

  • Professor, University of Pittsburgh School of Medicine, Department of Dermatology
  • Professor, University of Pittsburgh School of Medicine, Department of Immunology

An overview of Dr. Larregina's research can be found here.

Education & Training

  • B.S., National University of La Plata, Buenos Aires, Argentina
  • M.D., National University of La Plata, Argentina
  • Ph.D., University of Buenos Aires, Argentina
  • Pathologist, University of Buenos Aires, Argentina

Representative Publications

·        Larregina AT (Corresponding author), Morelli AE, Spencer LA, Logar A, Watkins SC, Thomson AW and Falo LD Jr. Dermal CD14+ cells differentiate into Langerhans cells in the presence of GM-SCF, IL-4 and TGF- b1. Nature Immunol. 2: 1151-1158, 2001.

·        Larregina AT (Corresponding author), Morelli AE, Tkacheva Olga , Erdos G, Watkins SC, Thomson AW and Falo LD Jr. Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells through terminal differentiation. Blood. 103: 811-819. 2004.

·        Morelli AE, Rubin P, Tkacheva  O, Zahorchack A, Thomson AW, Falo LD Jr. and Larregina AT. (Corresponding author). Induction of CD4+ T cell responses by different subpopulations human skin dendritic cells.  J Immunol. 175: 7905-7915, 2005.

·        Mathers AR and Larregina AT (Correponding author).  Professional Antigen Presenting Cells of the Skin. Immunol Res. 36: 127-136, 2006.

·        Mathers AR, Tckacheva OA, Janelsins BM, Shufesky WJ, Morelli AE, and Larregina AT. (Corresponding author). In vivo signaling through the neurokinin 1 receptor favors transgene expression by Langerhans cells and promotes the generation of Th1-Tc1 biased immune responses. J Immunol. 78:7006-7017, 2007.

·        Mathers AR,  Janelsins BM, Rubin JP, Tkacheva OA, Shufesky WJ, Morelli AE, and Larregina AT. (Corresponding author). Differential capabilities of human cutaneous dendritic cell subsets to initiate Th17 responses. J Immunol. 182: 921-933, 2009.        

·        Janelsins BM, Mathers AR, Tkacheva OA, Erdos G, Shufesky WJ, Morelli AE, and Larregina AT. (Corresponding author). Pro-inflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood. 113: 3017-3026, 2009.

·        Divito SJ, Morelli AE, and Larregina AT (Corresponding author).  Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases. Immunol Res. 50: 195-201, 2011.

Sumpter TL, Ho CH, Pleet A,  Tkacheva OA, Shufesky WJ, Rojas-Canales DM, Morelli AE, and Larregina AT (Corresponding author).  Autocrine hemokinin-1 functions as endogenous adjuvant for IgE-mediated mast cell inflammatory responses. J Allergy Clin Immunol. 135: 1019-1030, 2015. 

·        Larregina AT (Corresponding author), Divito SJ and Morelli AE. Nociceptive neurons as targets to control immunity: Potential relevance for transplantation. Am J Transplant. 15: 1472-1474, 2015.  

Research Interests

Cutaneous Immunology. Role of cutaneous neuroinflammation. Study of the relevance of pro-inflammatory neuropeptides as stimulators of dendritic cell , mast cells and T cells. immunostimulary function; use of antagonists of the pro-inflammatory neurokinin-1 receptor for the prevention and treatment of skin inflammatory and autoimmune diseases; study of the relevance of human cutaneous DCs at different maturation stages.

Research Grants

Grant Number: R01 AR068249​ 

Title: Manipulating Cutaneous Neuroimmunity to Treat Contact Dermatitis

Role: Co-Principal Investigator

Source of funding: NIH / NIAMS

Years Inclusive: 7/1/2015-6/30/202

 

Grant number: R01HL130191.

Title: Exosomes as paracrine signal mediators in cardiac allograft rejection

Role: Co- Investigator.

Years inclusive: 02/1/2016 – 1/31/2020.

Source of funding: NIH / NIHLBI

 

Grant Number: K01 AR067250

Title: Manipulating Neuropeptide Receptors in Mast Cells for Atopic Dermatitis Treatment.

Role: Scientific Mentor.

Years Inclusive: 7/1/2015 -6/30/2020